Life Sciences Case Study

Royale International contributed to a memorable, life-saving mission by arranging delivery of bone marrow for a child in urgent need of a transplant. The logistical requirements were extremely complex and challenging. Let’s have a look at the Life Sciences Case Study!

Background

An 8-year-old girl in Israel suffering from cancer was in desperate need of life-saving treatment. She received advice from her doctors to undergo an allogeneic bone marrow transplant. For this procedure to go ahead, the doctors needed to identify a donor who could provide her with matching stem cells. 

For bone marrow transplants, the donor’s cells need to match with the patient’s tissue type and human leukocyte antigens (HLAs). This match-making process ensures the recipient’s body ‘accepts’ these new cells and avoids any potential side effects. Bone marrow only has a 72-hour lifespan outside of the body. Which is why the delivery lead time had to be as short as possible, ensuring the cells remained alive and viable for use. After intensive research, the doctors managed to find a matching donor located in Adana, Turkey. 

Challenge

The biggest obstacle for this mission was the absence of international flights to transport the bone marrow from Turkey to Israel. Due to the Covid-19 pandemic, most flights were cancelled with governments tightening travel and imposing cross-border restrictions. 

In addition, the government in Israel had suspended all international flights in and out of Tel Aviv’s Ben Gurion Airport to combat the spread of new Covid-19 strains. This made it near impossible to get shipments in and out of the country. 

An exception to this flight ban was a “daily rescue flight” from Germany to Israel transporting urgent supplies. Royale International initially managed to arrange a flight from Adana Airport up to Frankfurt Airport to connect on the rescue flight to Tel Aviv. We secured a seat on this rescue flight by arranging all the required documents and negative Covid-19 test results for the On-Board courier.  

The issuance of the travel permit enabled us to transport the bone marrow from Frankfurt to Tel Aviv. However, bad weather delayed the arranged flight from Adana, Turkey to Frankfurt, Germany. That could cause delay to meet the connecting flight to Tel Aviv. Brought a critical problem as the bone marrow only had a 72-hour lifespan. As the next scheduled rescue flight would arrive too late. 

Solution 

In a matter of hours Royale International came up with a solution. Chartering an aircraft in Israel and arranging documentation and Covid-19 tests for all individuals involved in the delivery process. Tests for the aircrew and the ground staff were necessary to ensure the transport process adhered to all Covid-19 regulations. 

We arranged an Israeli On-Board Courier for the chartered flight from Tel Aviv direct to Adana. After the On-Board Courier landed in Adana. The courier was escorted to the hospital where he picked up the bone marrow shipment. Then immediately returned to the airport where the chartered aircraft and pilot were waiting for his return trip back to Tel Aviv. 

After arriving back in Tel Aviv, our courier underwent another Covid test and, upon receiving negative results, boarded our dedicated van to the destination hospital in Jerusalem.

Shortly after the bone marrow had been delivered by the courier at the hospital in Jerusalem. We have received news of the successful execution of the transplant.

Timeline for the bone marrow delivery

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